This paper presents a study that aims to investigate the implementation of the Total Productive Maintenance (TPM) program in the healthcare industry. The study was carried out at a major hospital in Jordan using semistructured interviews coupled with documents collection and analysis. A TPM implementation methodology has been developed for increasing medical devices utilization and decreasing their failures. The developed employees‟ working system and new responsibilities were explained through Autonomous Maintenance (AM), Preventive Maintenance (PM), and 5S Modeling, with a suggestion for additional working performance indicators. This paper is one of a few studies that investigate the applicability of manufacturing maintenance systems in other settings and that they can generate significant operational benefits.