Many neurodegenerative diseases share the same pathophysiology and etiologies, this led us to search for a product that may fit in the treatment of most of diseases, including neurological, cardiovascular, cancers, etc. Coenzyme Q10 is a natural product found in many kinds of beings like fish, beef, organ meat (liver, heart), whole grains, etc. Many studies on different animal models have concluded that coenzyme Q10 has neuroprotective effects against neurological disorders, improves mitochondrial functions, prevents oxidative stress and cellular death, stimulates cell growth, inhibits inflammation, and enhances neurogenesis. In addition, it decreases cerebral infarct size, inhibits platelet aggregation and blood thrombosis, and improves endothelial dysfunction. Coenzyme Q10 has important roles in different body systems ranging from cardioprotection, hepatoprotection, gastroprotection and nephroprotection to a documented function in slowing the aging processes. This article aims to summarize and discuss up-to-date experimental findings related to the mechanisms by which coenzyme Q10 and its analogs assist in treatment and thus improvement of many conditions in animals and human.