The main questions addressed in this paper are the following: what are the interventional factors that affect instructors' adoption of an e-Learning system and what are the relationships among these factors?. For this purpose a number of hypotheses were formulated. In this study, a framework was conceptualized based on an extended version of the Technology Acceptance Model (TAM) integrated with intervention factors. The findings of the study show that there is a significant positive relationship between management support, design characteristics, organizational support, training, perceived usefulness, perceived ease of use and intention to adopt e-Learning. Based on the study results, it was recommended that the Palestinian universities should intervene to promote the adoption of e-Learning system.