This study synthesized a novel series of ~55 Benzodioxol derivatives and evaluated their multitarget biological activities. In vitro and in vivo assays assessed their effects on AMPA receptors, COX enzymes, α-amylase, and cancer cell lines. Key findings revealed potent AMPA receptor modulation, suggesting therapeutic potential for Parkinson’s disease. Aryl acetate derivatives showed strong COX-2 inhibition, while select acetic acid and carboxamide compounds exhibited superior α-amylase inhibition, outperforming Acarbose in reducing blood sugar levels. Molecular docking studies clarified binding interactions with AMPA receptors and α-amylase, while bioavailability predictions (Molinspiration, Lipinski’s rule of five) aligned with experimental data. Overall, this work identifies promising candidates for neurological disorders, NSAID development, and diabetes treatment.

Conference Title

VII. INTERNATIONAL CONFERENCE ON NATURAL SCIENCES AND TECHNOLOGIES

Conference Country

Turkey

Conference Date

July 12, 2025 - July 14, 2025

Conference Sponsor

Eskisehir Technical University