12C/13C isotope exchange for the synthesis of D‑[13C]phenylalanine by using [13C]CO2 and binol chiral aldehyde receptor
- Publication Type
- Original research
- Authors
- Fulltext
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Isotope labeling of α-amino acids is a crucial tool for drug discovery and understanding biochemical processes. The goal
for this work was to develop a fast exchange condition to prepare D-[13C]phenylalanine in a short time with high incorporation of 13C isotope, which could be translated to 11C-α-amino acid. In this work the exchange reactions on preformed imine
carboxylate by using [13C]CO2 gave some evidence that the fast exchange to enable direct radiolabeling of α-amino acids,
using [11C]CO2, could be possible.
Journal
- Title
- Journal of Radioanalytical and Nuclear Chemistry
- Publisher
- Springer (Springer Nature)
- Publisher Country
- Germany
- Indexing
- Scopus
- Impact Factor
- 1.6
- Publication Type
- Prtinted only
- Volume
- 334
- Year
- 2025
- Pages
- 3669–3682