This study aimed to reveal the effectiveness of e-learning in the light of the spread of the Coronavirus from Khadouri University instructors' perspective. To achieve the goals of the study descriptive analytical approach was used. The study sample consisted of (50) instructors from Khadouri University who taught during the spread of Coronavirus using the e-learning system. Data were collected through a questionnaire which its reliability reached to (0.804) and applied on the study sample. The results revealed that the effectiveness of e-learning in the light of the spread of the Coronavirus from the study sample perspective was medium, the evaluation of the continuity of e-learning, its obstacles, the interaction of instructors with e-learning and the interaction of students with e-learning in light of the spread of the Coronavirus was medium. The researchers recommended conducting training courses in the field of e-learning for both instructors and students, help get rid of all the obstacles that prevent utilizing from the e-learning system, and combine face-to-face and e-learning in higher education institutions in the future.