Course Title

Medicinal chemistry I

Course Number

7303301

Instructor Name

Mohammed Hawash

Contact Information

[email protected]

Semester(s) and academic year(s)

First Semester 2025
First Semester 2024
First Semester 2023
Second Semester 2022
First Semester 2022
First Semester 2021

Compulsory / Elective

Compulsory

The aim of this course is to introduce the basic concepts of medicinal chemistry. Study the physicochemical properties of the drugs and study their distribution, metabolism and excretion. The course will discuss specific drug classes by covering its chemistry, some synthesis, mechanism of action and its structural activity relationship (SAR) of antibacterial agents, antiviral agents, NSAIDs, and steroidal anti-inflammatory drugs

1. Introduces different drug targets.

2. Addresses the relationship between chemical structure and biological activity of anti-infective agents and NSAIDs.

3. Apply principles of drug metabolism and pharmacokinetics to predict drug behavior in the body.

4. Analyze structure-activity relationships (SAR) to inform drug design and optimization.

5. Demonstrate knowledge of the synthesis and mechanism of action of anti-infective agents and NSAIDs.

1. Recognize and describe the different drug targets, identify the pharmacokinetic parameters of the drugs.
2. illustrate the SAR of different types and classes of drugs (anti-infective drugs, steroidal and non-steroidal anti-inflammatory drugs).
3. Experimenting with therapeutic action, pharmacokinetics, and formulation of chemical compounds according to their structure
4. Collaborate with peers to solve drug metabolism problems using medicinal chemistry knowledge

- An Introduction to Medicinal Chemistry by Graham L. Patrick, fifth edition. Oxford University Press, 2013

- Journal of medicinal chemistry

- ACS medicinal chemistry letters

- European journal of medicinal chemistry