Abstract: Purpose: The purpose of the study is to investigate the influence of Innovation and Creation (I&C), Research and Development (R&D) and Intellectual Property Rights (IPRs) on Jordanian Pharmaceutical Manufacturing (JPM) Industry's Business Performance (BP), through examining the managers’ perceptions regarding significance and potential use of IPRs indicators to leverage JPM Industry's’ BP. Design/Methodology/Approach: The study surveyed executives, top and middle managers working at the 15 JPM Organizations by means of a questionnaire. Practical data were used in the empirical analysis collected from 101 managers out of 250 managers of the mentioned organizations. Statistical techniques such as descriptive statistics, t-test, ANOVA test, correlation, multiple regressions and stepwise regression were employed. To confirm the suitability of data collection instrument, a Kolmogorov-Smirnov (K-S) test, Cronbach’s Alpha and factor analysis were used. Findings/Results/Conclusions: The results of the study indicated a positive significant relationship between R&D and IPRs with JMP organizations' BP. However, the results showed that Innovation and Creation, and R&D have positive and significant effect on performance, while IPRs has negative but not significant effect on performance. The results also indicated that the managers in JPM organizations were having high preference of Innovation and Creation, and R&D indicators, while they have low preference of IPRs indicators. Moreover, findings suggest that the JPM organizations performance can clearly explain productivity and profitability more than market valuation. Key Words: Innovation and Creation (I&C), Research and Development (R&D), Intellectual Property Rights (IPRs), Jordanian Pharmaceutical Manufacturing (JPM) Industry, Business Performance (BP).