PURPOSE: To evaluate the effect of high flux membrane dialysis on total serum testosterone (TST) level. 
METHODS: Total of 60 male with end stage renal disease (ESRD) whose mean age was (54.02 ± 13.40 years) were included. TST and Hct serum levels were measured before and after hemodialysis. The change in TST and Hct value were calculated. The correlation between the change in TST and Hct was assisted. The mean period of hemodialysis program was (46.5±27 months) and all patients undergo standard hemodialysis program three times per week, four hours period for each session. Patients with prostatic cancer or previous history of prostatic surgery or liver insufficiency or who taking androgen therapy were excluded.
RESULTS: Significant increment in serum level of testosterone values after hemodialysis occurred; the mean values of TST before and after dialysis were (3.13±1.44 ng/ml, 4.17±2.04 ng/ml) respectively and (r=0.78,p=0.001). The pre- and post-hemodialysis Hct levels were (32.31% ± 3.90% and 35.27% ± 4.89%) respectively and (r=0.754, p=0.001). The mean percentage of changes in TST and Hct values after hemodialysis were (35±0.33%) and (9±0.1%) respectively. There was a correlation detected between the change in TST and Hct level (r=0.277, p=0.032)
CONCLUSIONS: High flux membrane dialysis does not filtrate testosterone molecule. Hemodialysis resulted in statically significant elevation in serum testosterone level. Hemoconcentration is seems to be the most valid explanation for the increment in serum testosterone level. Before hemodialysis the majority of the patients have serum testosterone levels ranging from low to borderline. Therefore supplements of androgens may be of clinical benefit.
 

Conference Title

26th Turkish International Urology Meeting

Conference Country

Turkey

Conference Date

Nov. 1, 2017 - Nov. 1, 2021

Conference Sponsor

Turkish association of urology