A number of naringin based heterocyclic derivatives dioxolane and imidazolidine have been synthesized and evaluated for their antioxidant and biological activities. The chemical structures of newly synthesized

compounds were verified on the basis of spectral and elemental methods of analysis. Investigation of antibacterial activity of these compounds was determined by measuring MIC value using broth micro dilution method for Gram-positive and Gram-negative bacteria, among the various synthesized compounds. Dioxolane showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0.125mg/ml, in addition this compound exhibit the best antioxidant activity with inhibition concentration (IC50) of 18.7 μg/mL, compared with other semi synthetic derivative.

Conference Title

Second Palestinian International Graduate Conference on Natural, Medical and Health Sciences and Humanities (SPIGCNMHSH 2017) An-Najah National University New Campus, Nablus, Palestine, April 20, 2017

Conference Country

Palestine

Conference Date

April 20, 2017 - April 20, 2017

Conference Sponsor

An - najah national uneversity