Synthesis, DFT and antibacterial studies of new Schiff base derived from nicotinohydrazide
- Publication Type
- Conference Paper
- Authors
Abstract
A new Schiff base N'-( (5-bromothiophen-2-yl) methylene ) nicotinohydrazide wasisolated andcharacterizedasZ-isomer as seen in the Scheme.
The synthetic condensation reaction was monitored by FT-IR and UV- visible as well as DFT calculation. The structure of desired compound was experimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR
spectral, TG/DTG. 1H-NMR and DFT-computational calculation supported Z- isomer as favorited product over E one. Good agreement between experimental and theoretical calculatation were obtained. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.
Keywords: FT-IR, condensation, TG, Schiff bases, DFT.
Conference
- Conference Title
- Second Palestinian International Conference on Material Science and Nanotechnology (PICNM2016)
- Conference Country
- Palestine
- Conference Date
- March 23, 2016 - March 24, 2016
- Conference Sponsor
- An Najah National University