Synthesis, DFT and antibacterial studies of new Schiff base derived from nicotinohydrazide
Publication Type
Conference Paper


A new Schiff base N'-( (5-bromothiophen-2-yl) methylene ) nicotinohydrazide wasisolated andcharacterizedasZ-isomer as seen in the Scheme.

The synthetic condensation reaction was monitored by FT-IR and UV- visible as well as DFT calculation. The structure of desired compound was experimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR

spectral, TG/DTG. 1H-NMR and DFT-computational calculation supported Z- isomer as favorited product over E one. Good agreement between experimental and theoretical calculatation were obtained. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.

Keywords: FT-IR, condensation, TG, Schiff bases, DFT.


Conference Title
Second Palestinian International Conference on Material Science and Nanotechnology (PICNM2016)
Conference Country
Conference Date
March 23, 2016 - March 24, 2016
Conference Sponsor
An Najah National University