Nursing profession is high demand career, nurses usually are exposed to situations that affect their quality of working life (QoWL), the aim was to measure the quality of working life among nurses in pediatric departments. We used a quantitative cross-sectional study approaches to assess the quality of working life (QoWL) of nurses working in the four pediatric departments in Faro Hospital Portugal, using Work-Related Quality of Life (WRQoL) scale. The findings showed that most of respondent nurses experienced low QoWL, there was no effect of studied variables such as age, gender, education level and other variables on QoWL. As a result nurses need more efforts and programs to enhance and achieve good QoWL. Further researches needed to find the causes of low QoWL.