: Despite the modern medicinal chemistry in designing new therapeutic agents by using different new innovative techniques in molecular modeling and combinatorial chemistry, beside to their expensive cost, infectious diseases continue to be one of the greatest health challenges worldwide (Cohen, M. L., 2000). The main disadvantages for conventional antibiotics are the development of multiple drug resistance and adverse side effects. Recent advancement in nanoscience and nanotechnology has expanded our ability to design and construct nanomaterials with targeting, therapeutic, and diagnostic functions (Cheon, J., et al. 2008; Huang, W. C., et al. 2008). Among nanotechnology-derived materials, carbon nanotubes (CNTs) have stimulated a great interest for biomedical applications because of their unique mechanical, electrical, thermal and spectroscopic properties (Liu, Z.; et al. 2009). Nevertheless, advances in these directions have been hampered by the insolubility of CNTs in most solvents, and most importantly in water where they exist as ropes and large bundles. To overcome these problems we have recently development various approximations for the water solubilzation of SWCNTs (Assali, M. et al.; 2009, 2010).
So, here we aim to develop a new nano-antibiotic based on carbon nanotubes by functionalizing them covalently with Ciprofloxacin antibiotic and proposing that the large surface area of CNT and/or this new nan-prodrug will prevent the bacteria to throw them out once they penetrate the membrane, figure 1.
In the present communication, the following points will be discussed: (i) the modular synthetic strategies developed for the synthesis of the nanoconjugate, (ii) the characterization of the formed nanoantibiotic by various analytical techniques like AFM, UV-Vis, FTIR, TGA, and (iii) the ability of the prepared nanosystems to specifically attack different types of bacteria.