Arum palaestinum Boiss. leaves considered one of the most edible wild plant in Palestine also one of the medicinal plant utilized for treatment various diseases specially cancer. The present study sought to evaluate the exhaustive extract yields percentages for Solomon's Lily (Arum palaestinum Boiss.) leaves from all of the regions in the West Bank/Palestine (Nablus, Jenin, Tubas, Tulkarm, Salpheet, Qalqilya, Ramallah, Jericho, Jerusalem, Bethlehem, Hebron) to investigate the best region in Palestine that have the strongest anticancer activity which can be helpful in manufacturing foods supplements, cosmeceuticals and pharmaceuticals formulations. By using exhaustive extraction method, the yield of organic and water extraction experimental method was assessed, with steeping the plant in ethanol, water and hexane to extract all the chemical ingredients without destroying or changing their chemical constituents. It is found that the best aqueous and organic yields were in Salfeet region (4.8%, 3.24 %, respectively) while the lowest aqueous yield and organic yield was in Jericho (2.64%, 0.76%, respectively). In recommendation for pharmaceutical companies, Salfeet region was the best area for cultivation Arum palaestinum Boiss. plant for manufacturing evidence based standardized pharmacological active pharmaceutical forms also for further scientific researches.