Albendazole is determined by differential-pulse adsorptive cathodic stripping voltammetry at a hanging mercury drop electrode using the reduction peak of its copper(II) complex at −0.28V at an accumulation potential 0.0V vs. Ag/AgCl electrode. The optimum conditions of pH, accumulation potential and accumulation time were studied. The calibration graph for the determination of albendazole was linear in the range 3.0X10⁻⁸ - 9X10⁻⁷M with a relative standard deviation of 2.8%. The detection limit was 1.0X10⁻⁸M after 180s accumulation at 0.0V. The effect of common excipients and metal ions on the peak height of albendazole was studied. The presence of Cu²⁺ ions forms a stable complex with albendazole which is strongly adsorbed at the mercury electrode surface. The method was applied to the determination of the drug in commercially available dosage forms.

Title

Analytical Letters, 32; 2965-2975

Publisher

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Publisher Country

Palestine

Publication Type

Both (Printed and Online)

Volume

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Year

1970

Pages

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