A New Synthetic Approach to Indazoles Synthesis
- Publication Type
- Original research
- Authors
- A. N. Zaid
- Pier Giovanni Baraldi
- Barbara Cacciari
- Giampiero Spalluto
- Romeo Romagnoli
- Giovanni Braccioli
- Maria J. Pineda de las Infantas
Stobbe condensation of 3-alkyl- or aryl-4-formylpyrazoles 3a-f with diethyl succinate in the presence of potassium t-butoxide, followed by intramolecular ring closure (Ac2O-NaOAc), afforded the corresponding indazole derivatives 5a-f in 65-85% overall yield. These compounds are good starting materials for transformation to biologically active molecules, such as new pyrazole analogs of the left-hand segment of the potent natural antineoplastic agent CC-1065.
Journal
- Title
- Synthesis ; 1997(10): 1140-1142
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 1997
- Pages
- --