Crash Prediction Models (CPMs) that incorporate design consistency measures for rural two-lane, two-way roadways in the West Bank of Palestine have been developed. This study aims at comparing the effectiveness of the resulting models with those, which rely solely on geometric design characteristics. Several two-lane rural highways located in the West Bank, Palestine for a total length of about 118 km were chosen for analysis based on limitations in available data. The selected highway sections encompass a variety of highway classifications, locations, terrains, and characteristics. Crash data were obtained from the Israeli Central Bureau of Statistics and included number of crashes and their type for years 2003 through 2012.