Results from fire resistance experiments on six RC beams are presented in this paper. The test variables included concrete strength (permeability), support conditions, fire scenario, and load ratio. Data from fire tests are used to illustrate the comparative performance of high strength concrete (HSC) and normal strength concrete (NSC) beams under fire conditions. Also, data from the tests is used to validate a macroscopic finite-element model specifically developed for tracing the fire response of RC beams. Results from the tests and numerical studies show that HSC beams have lower fire resistance than that of NSC beams. It is also shown that HSC beams exhibit higher levels of spalling which is largely influenced by the permeability of concrete, type of fire exposure, load level, and restraint conditions. Similarly, the type of fire scenario, axial restraint, and load level have significant influence on the overall fire resistance of RC beams. These factors are to be considered for evaluating the fire resistance of RC beams under fire conditions.