Abstract

Background: Cardiopulmonary bypass (CPB) is a common technique in cardiac surgery, however, it is associated with acute kidney injury. The type of solution in the CPB circuit can potentially affect surgery outcome through affecting several organs and body homeostasis. The optimal prime solution for the CPB) circuit in adult cardiac surgery has not yet been defined. Mannitol is widely used in the priming solution for CPB even though there is no clear consensus on the role of mannitol in cardiac surgery.

Purpose: The purpose of this study was to investigate the effect of mannitol in the CPB prime solution on renal function during cardiac surgery and post-operative in selected private hospitals in Nablus City

Design and method: prospective cohort study design conducted at An-Najah National University Hospital and specialized Arab hospital. A sample of 120 patients was studied. The patients had cardiac surgery and they had preoperative normal renal function.

Results: The use of mannitol in the CPB prime solution was associated with a decrease in creatinine and BUN readings levels in the postoperative period (postoperative period mean =0.7692 ± 0.26068, and 18.3917 ± 7.56629mg/dl, respectively; p-value<0.001) and an increase in GFR levels in the postoperative period (postoperative period mean = 112.27861 ± 1.43604, p-value<0.001) indicating and improvement in renal function following cardiac surgery.

Title

Jordan Journal of Pharmaceutical Sciences

Publisher

Jordan Journal of Pharmaceutical Sciences

Publisher Country

Jordan

Indexing

Scopus

Impact Factor

0.0

Publication Type

Both (Printed and Online)

Volume

18

Year

2025

Pages

377-388