Overcoming the skin barrier is crucial for the treatment of skin infections affecting the deep skin layers. Delivery of therapeutics
to these layers is considered the key to efficient treatment. The objective of this study is to develop and investigate a
nanovesicular system to improve the penetration of the antibacterial drug, clindamycin, into the skin. The carrier employed
in this investigation is a transethosomal carrier consisting of phospholipid nanovesicles that possess flexible and adaptable
characteristics due to the inclusion of surfactants and cosolvents like ethanol and propanediol. System characterization by
atomic force microscopy and dynamic light scattering revealed the presence of enclosed, spherical nanovesicles. Additional
pH measurements indicated that the system is appropriate for topical application. The drug release rate in the in vitro tests
was shown to be dependent on the viscosity of the system. The results indicated that higher concentrations of the thickening
agent, hydroxypropyl cellulose, led to sustained release characteristics. Furthermore, in vitro penetration experiments
indicated an enhanced penetration of clindamycin into the skin tissue as compared to traditional formulations. These findings
point towards the significance of the transethosomal carrier in facilitating the penetration of drugs into the epidermis leading
to better management of bacterial skin infections.

Title

Bionanoscience

Publisher

Springer Nature

Publisher Country

United Kingdom

Indexing

Thomson Reuters

Impact Factor

3.0

Publication Type

Both (Printed and Online)

Volume

15

Year

2025

Pages

224