Recent research reported inhibitory effects of Eriobotrya japonica leaf extracts on DPPH free radicals and α-amylase, α-glucosidase, and lipase enzymes. These enzymes were linked to the etiology of diabetes mellitus, obesity, and oxidative stress.The current study is aimed at determining the phytocontents of E. japonica aqueous extract leaves and exploring theirpotential antioxidant, anti-α-amylase, anti-α-glucosidase, and antilipase activity using reference phytochemical and biochemicalassays. The phytochemical tests on the E. japonica aqueous extract confirmed the presence of alkaloids, glycosides, tannins,saponins, phytosteroids, carbohydrates, and phenols. The total phenol and tannin contents of the E. japonica aqueous extractwere 21 64 ± 0 89 mg of GAE/g and 1 72 ± 1 mg of CAE/g, respectively. E. japonica aqueous extract had inhibitory effects onDPPH free radicals (IC50 of 7 7 ± 3 11 μg/mL) and α-amylase (IC50 = 141 ± 0 35 μg/mL) compared with Trolox and acarbose(6 3 ± 0 12 and 28 18 ± 1 22 μg/mL, respectively). Moreover, E. japonica aqueous extract inhibited α-glucosidase(IC50 = 39 81 ± 0 74 vs. 37 15 ± 0 33 μg/mL inhibition by acarbose) and lipase (IC50 = 316 2 ± 0 87 vs. 12 3 ± 0 33 μg/mLinhibition by orlistat). In conclusion, the current results suggest that E. japonica aqueous extract possesses strong antioxidant,anti-α-glucosidase, anti-α-amylase, and antilipase activities with potential applications in the treatment and prevention ofobesity, diabetes mellitus, and oxidative stress

Title

BioMed Research International

Publisher

Wiley

Publisher Country

United States of America

Indexing

Thomson Reuters

Impact Factor

2.3

Publication Type

Both (Printed and Online)

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Year

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Pages

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