Purpose The objective of this study is to formulate a nanoemulgel using Punica granatum (P. granatum) seed oil and study the antibacterial, anticancer, and anti-inflammatory properties. Methods The process to formulate a nanoemulsion from P. granatum seed oil involved using the self-nanoemulsifying technique, with Span 80 and Tween 80 serving as the emulsifying agents. Carbopol hydrogel was combined with the nanoemulsion to produce the nanoemulgel. The particle size, polydispersity index (PDI), rheological behavior, antibacterial, cytotoxic, and anti-inflammatory properties were subsequently examined. Results The nanoemulsion formulation with a PDI of 0.229 and a particle size of 189.44 nm was identified as the optimal formulation. The P. granatum seed oil nanoemulgel showed significant effects on MRSA, K. pneumoniae, and C. albicans, with zone inhibition diameters of 29 ± 1.1 mm, 26 ± 1.8 mm

Title

)Biomedicine (Taipei

Publisher

China Medical University

Publisher Country

China

Indexing

Thomson Reuters

Impact Factor

2.5

Publication Type

Both (Printed and Online)

Volume

15

Year

2025

Pages

24–35