Curcumin is classified as a chemotherapeutic medication because of its potential against
numerous cancer cell lines and ability to inhibit cancer cell proliferation. Despite these findings,
curcumin has yet to be commercialized as a drug due to its low water solubility, low absorption,
and restricted bioavailability. As a result, there is a demand for water-soluble curcumin with
improved solubility, bioavailability, and thus bioactivity. In this study we report the synthesis and
the anticancer activities of water-soluble curcumins derivatives with alkyl sulfonate moiety. The
target water-soluble curcumin with alkyl sulfonate moieties was created utilizing a straightforward
technique that involved reacting curcumin with various sultones. The cytotoxic (24 h) and
cytostatic (72 h) anticancer effect on breast carcinoma (MCF-7), liver carcinoma (HepG2), skin
melanoma (B16–F110), colon human cancer and HeLa cervical carcinoma cell lines viability %
via MTT assay were determined for the prepared derivatives. Results showed that curcuminderived
compounds have a pronounced cytostatic anticancer effect rather than cytotoxic one in
relation to the compound type, cancer cell line type, and examined concentration compared to
curcumin. The curcumin sulfonates outperformed curcumin activity against the tested cancer
cells and showed to be powerful anticancer candidate drugs as supported by the theoretical
calculations. This is evident by their high capacity to form H-bonding during docking with the
amino acid side chains and the Vina docking score.

Title

Helion

Publisher

Elsevier

Publisher Country

Netherlands

Indexing

Scopus

Impact Factor

4.0

Publication Type

Prtinted only

Volume

10

Year

2024

Pages

214