Abstract
Background Plants have historically been a rich source of medicinal compounds, with many modern
pharmaceuticals derived from botanical origins. In contemporary healthcare, there is a resurgence in utilizing
botanical substances as recognized medicinal agents. This study delved into understanding the phytochemical
makeup and the multifaceted biological activities of an aqueous extract from Cymbopogon citratus (C. citratus). The
investigated activities were its effect on AMPA receptors, antioxidant capacity, anti-lipase, anti-α-amylase actions,
cytotoxicity, and antimicrobial properties.
Methods The extract of C. citratus received a comprehensive investigation, which included the study of its
phytochemical composition, assessment of its antioxidant and anti-lipase properties, evaluation of its capacity to
inhibit α-amylase, analysis of its impact on cell viability, and assessment of its antimicrobial activity. The approaches
are used to clarify the complex physiological and biochemical characteristics.
Results The results were compelling; receptor kinetics had a marked impact, notably on the GluA2 subunit.
Regarding its medicinal potential, the extract demonstrated potent antioxidant and anti-diabetic activities with IC50
values of 15.13 and 101.14 μg/mL, respectively. Additionally, it displayed significant inhibitory effects on the lipase
enzyme and showed cytotoxicity against the Hep3B cancer cell line, with IC50 values of 144.35 and 148.37 μg/mL. In
contrast, its effects on the normal LX-2 cell line were minimal, indicating selectivity.
Conclusion The aqueous extract of C. citratus shows promising therapeutic properties. The findings advocate for
further research into its compounds for potential isolation, purification, and in-depth pharmacological studies,
especially in areas like nervous system disorders, diabetes, obesity, and combating oxidative stress.

Title

BMC Complementary Medicine and Therapies

Publisher

Springer

Publisher Country

Germany

Indexing

Thomson Reuters

Impact Factor

4.0

Publication Type

Both (Printed and Online)

Volume

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Year

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Pages

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