Plant-derived compounds, including flavonoids, sesquiterpenes, and others, have been widely investigated for their role in cancer treatment. Here, we highlight the significance of some natural compounds (β-caryophyllene oxide) on enhancing doxorubicin’s chemotherapeutic drug
cytotoxicity. We also determined a novel mechanism of cytotoxicity for β-caryophyllene oxide by revealing its ability to bind with the DNA. This potentially causes its cytotoxicity when added alone and its ability to enhance doxorubicin’s cytotoxicity. We also show that some natural compounds (epicatechin) may provide protection to cancer cells against doxorubicin’s toxicity. This is most likely caused by their antioxidant behaviour which potentially suppressed the doxorubicin-induced reactive oxygen species (ROS) resulting in a decrease in its cytotoxicity. Moreover, similar suppression in the cytotoxicity of caryophyllene oxide was noticed when incubated with the other flavonoids (i.e. epicatechin).

Title

Natural Product Communications

Publisher

Sage Journals

Publisher Country

United Kingdom

Indexing

Scopus

Impact Factor

1.5

Publication Type

Both (Printed and Online)

Volume

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Year

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Pages

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