Levofloxacin is a widely used fluoroquinolone antibiotic. In this study, the drug was examined using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The study sought to understand the mechanism of the drug's thermal decompaction, as well as its thermal stability and behavior at elevated temperatures for environmental applications. The TGA was done using various heating rates under N2 gas flow. The isoconversional methods of Kissinger-Akahira-Sunose (KAS) and Friedman were used to determine the  decomposition's effective activation energy (Eα) based on extent of conversion (α). The Eα values of levofloxacin's decomposition ranged from 50-120 and 20-70 kJ/mol for KAS and Friedman, respectively.

Title

Moroccan Journal of Chemistry

Publisher

Moroccan Center of Development and Science

Publisher Country

Morocco

Indexing

Scopus

Impact Factor

2.4

Publication Type

Both (Printed and Online)

Volume

13

Year

2024

Pages

10