Abstract
Background
High-sensitive cardiac troponin T (h-cTnT), which serves as a marker for myocardial damage,
has also been linked to adverse outcomes in asymptomatic hemodialysis patients. This
study aims to explore the correlation between interleukin-6 (IL-6) and h-cTnT in asymptomatic
hemodialysis patients to unravel the relationship between inflammation and cardiovascular
risk.
Methods
A cross-sectional study involving 81 patients was conducted from November 2022 to March
2023 at An-Najah National University Hospital in Palestine. We gathered clinical data,
including comorbidities, and obtained blood samples for measuring IL-6 and h-cTnT levels.
We performed statistical analyses, including correlation tests and linear regression, to
assess the associations between these variables.
Results
The study revealed a notable increase in both h-cTnT and IL-6 levels, and a significant correlation
between the two (rho = 0.463, P<0.001) in asymptomatic hemodialysis patients.
Likewise, h-cTnT levels displayed positive correlations with age (rho = 0.519, P<0.001) and
negative correlations with albumin (rho = -0.297, p = 0.007) and transferrin saturation (rho =
-0.227, P = 0.042). IL-6 levels exhibited correlations with age (rho = 0.422, P<0.001), albumin
(rho = -0.389, P<0.001), iron (rho = -0.382, P<0.001), and transferrin saturation (rho =
-0.362, P = 0.001). Notably, higher h-cTnT levels were associated with diabetes, hypertension,
a history of coronary artery disease, cerebrovascular accidents, older age, and male
gender.

Title

Plos one

Publisher

Public Library of Science

Publisher Country

United States of America

Indexing

Scopus

Impact Factor

2.9

Publication Type

Online only

Volume

19

Year

--

Pages

e0296965