Abstract
Background
End-stage renal disease (ESRD) patients often experience accelerated bone turnover, leading
to osteoporosis and osteopenia. This study aimed to determine the prevalence of osteoporosis
in Peritoneal Dialysis (PD) patients using bone mineral density (BMD)
measurements obtained through dual-energy X-ray absorptiometry (DEXA) scan and to
explore any possible associations with clinical and biochemical factors.
Methods
In this cross-sectional study, we enrolled 76 peritoneal dialysis patients from the dialysis
center at An-Najah National University Hospital in Nablus, Palestine. We used the DEXA
scan to measure BMD at the lumbar spine and hip, with values expressed as T-scores. We
conducted a multivariate analysis to explore the relationship between BMD and clinical and
biochemical parameters.
Results
Over half (52.6%) of the PD patients had osteoporosis, with a higher prevalence observed
among patients with lower BMI (p<0.001). Higher alkaline phosphatase levels were found
among osteoporotic patients compared to non-osteoporotic patients (p = 0.045). Vitamin D
deficiency was also prevalent in this population, affecting 86.6% of patients. No significant
correlation was found between 25 vitamin D levels and BMD. No significant correlation was
found between Parathyroid hormone (PTH) levels and BMD.

Title

Plos one

Publisher

Public Library of Science

Publisher Country

United States of America

Indexing

Scopus

Impact Factor

2.9

Publication Type

Online only

Volume

19

Year

2024

Pages

e0301814