ABSTRACT: This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms,
specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The
research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl
methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and
delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS)
based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the
preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly
investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between
ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited
an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of
3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized
medicine.

Title

ACS Biomaterials Science & Engineering

Publisher

ACS Publisher

Publisher Country

United States of America

Indexing

Thomson Reuters

Impact Factor

5.4

Publication Type

Both (Printed and Online)

Volume

10

Year

2024

Pages

3833-3841