Antitumor, antiviral, antimicrobial and antioxidant activities were reported
for Euphorbia helioscopia usage in traditional medicine. Therefore, minimum inhibitory and
bactericidal concentrations (MIC, MBC) of E. helioscopia aqueous leaf and stem extracts
were evaluated by broth microdilution assay. As well as their antioxidant activity was
carried out using DPPH assay. Obtained results showed that MIC values of leaf extract
ranged from 0.78±0.0 mg/mL to 12.5±0.0 mg/mL and stem extract ranged from 3.125±0.0
mg/mL to 25±0.0 mg/mL. While, MBC of leaf and stem extracts had a range from 6.25±0.0
mg/mL to 50±0.0 mg/mL and 25±0.0 mg/mL to 50±0.0 mg/mL, respectively. The current
study demonstrated that E. helioscopia leaf and stem extracts had antioxidant activity.
One-way ANOVA test, the P values for the leaf and stem aqueous extracts were equal to
0.997 and 0.058, respectively. Consequently, both extracts showed no significant
difference relative to the standard ascorbic acid (P value > 0.01). In addition, statistical
analyses showed no significant differences between the tested concentrations of leaf
extract and tested concentrations of ascorbic acid at P value > 0.01. The same thing was obtained for tested concentrations of stem
aqueous extract, except at concentrations 7.81 and 3.91 μg/mL which showed DPPH inhibition percent 4.30±0.63 and 0.59±0.10,
respectively. This indicates that E. helioscopia has potential to serve as a natural antioxidant, which makes it a promising candidate for
therapeutic applications. Moreover, the positive antibacterial recorded data could potentially be used to develop potent drugs that
improve the management and treatment of variety bacterial illnesses.

Title

An-Najah University Journal for Research – A Natural Sciences

Publisher

An-Najah National University

Publisher Country

Palestine

Publication Type

Both (Printed and Online)

Volume

38

Year

2024

Pages

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