Abstract

New [Cu(bipy)(NNN)].2BF₄ water soluble dicationic complexes were made available starting from [Cu(bipy)₂Br]Br. The two complexes were isolated in excellent yield and identified via EDX, UV–vis., CV, SEM, FT-IR, CHN-EA, MS, and X-ray data analysis. The CV, IR and UV–Vis. were served to prove the compilation exchange of one bipy from [Cu(bipy)₂Br]Br via NNN co-ligands and 2Br counter anions by 2BF₄ anions via AgBF₄ reagent resulting complexes 1 and 2 with only AgBr precipitate side product. The XRD measurements for complex 1 confirmed the presence of Jahn-Teller distortion square-pyramidal around the Cu(II) center. Moreover, the H^…F/C-H^…F supramolecular synthon interactions within the lattice were recorded experimentally and then computed via MEP/MAC and HSA calculations. Additionally, the UV–Vis., IR, TGA and electrochemistry behavior have been used to monitor the ligands exchanged processes. The anti-inflammatory effectiveness of the desired complexes was evaluated by measuring their inhibitory effects on the enzymes lipoxygenase (LOX) and cyclooxygenase (COX-1 and 2). Furthermore, molecular docking surveys were implemented to explain the collected LOX/COX anti-inflammatory results.

Title

Ismail

Publisher

warad

Publisher Country

Palestine

Publication Type

Prtinted only

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Year

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Pages

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