Asymmetry diamine ligand was used to selectively prepare the trans-stereoisomer dimer of type [Br(N⋂N’)Cu(µBr)₂Cu(N⋂N’)Br] in a one-pot and high-yield sonosynthesis procedure. The trans-[Br(N⋂N’)Cu(µBr)₂Cu(N⋂N’)Br] square pyramidal structure was proved by XRD-crystal structure. Moreover, several physicochemical tools including EDX, FAB-MS, UV-vis, FT-IR and CHN-EA were used to check the dimer formula. Both Cu(II) ions exhibited one Br, 2half-bonds via 2µ-Br and two N-diamine to complete the five-coordinated bonds and form trans-Br₂-trans-(N'N’) complex with square pyramidal geometry. Additionally, the classical N-H…Br and non-classical C_Me-H…Br H-bonds interactions formed the novel S(9) synthons stabilizing the lattice of the dimer as inferred from the TG/DTG result. Molecular Electrostatic Potential (MEP), and HSA/XRD-interactions analysis compatible with chemical content and supported the formation of such synthons in the trans-stereoisomer-dimer lattice. The complex's solvatochromism and halochromism showed their sensitivity and proto-responsibility to the dissolved medium, respectively. Experimentally, the dimer been LOX enzyme inhibition more effectively than COX one, such seen was explained theoretically by molecular docking.

Title

Ismail

Publisher

warad

Publisher Country

Palestine

Publication Type

Prtinted only

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Year

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