The tumor microenvironment is recognized as a key factor in themultiple stages of cancer progression,mediating

local resistance, immune-escape andmetastasis. Cancer growth and progression require remodeling of the tumor

stromal microenvironment, such as the development of tumor-associated blood vessels, recruitment of bone

marrow-derived cells and cytokine processing. Extracellular matrix breakdown achieved by proteases like the fibrinolytic

factor plasmin and matrix metalloproteases is necessary for cell migration crucial for cancer invasion

andmetastasis. Key components of the fibrinolytic system are expressed in cells of the tumormicroenvironment.

Plasmin can control growth factor bioavailability, or the regulation of other proteases leading to angiogenesis,

and inflammation. In this review, we will focus on the role of the fibrinolytic systemin the tumor microenvironment

summarizing our current understanding of the role of the fibrinolytic factors for themodulation of the local

chemokine/cytokine milieu, resulting in myeloid cell recruitment, which can promote neoangiogenesis.

Title

Advanced Drug Delivery Reviews

Publisher

Elsevier

Publisher Country

United States of America

Publication Type

Prtinted only

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Year

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Pages

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