Sulfur Nanoparticle as an Effective HEK-293 Anticancer Agent
Publication Type
Original research
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The preparation of sulfur nanoparticles (S-NPs) by a fast precipitation low temperature approach using hydrochloric acid, sodium thiosulfate, and tetraoctylammonium bromide (TOAB) as a surfactant and stabilized has been reported in this work. The atomic content and purity of the S-NPs were supported by Energy Dispersive X-ray (EDX), and scanning electron microscopy (SEM) imaging supported the morphology and demonstrated nanoparticle aggregation. The progress of S-NPs preparation was monitored via UV-vis and optical activities behavior. The structure and the size of S-NPs were examined via powder X-Ray diffraction (PXRD) analysis. Transmission electron microscope (TEM) conforms the prepared S-NPs are in homogenous nano-sized with a value of 7-10 nm. The thermal stability of the desired S-NPs matrix was also determined by TG/DTG measurements. S-NPs' in vitro cytotoxic activities were evaluated against the HL-60 acute myeloid leukemia cell line, the HEK-293 kidney carcinoma cell line, and the HT-29 colon cancer cell line. The cytotoxicity of HEK-293 cell lines treated with S-NPs was higher than that of the other cell lines, according to the MTT assay

Journal
Title
Moroccan Journal of Chemistry
Publisher
University Mohammed Premier, Oujda Morocco in partenarship with the Association CEMADES
Publisher Country
Morocco
Indexing
Thomson Reuters
Impact Factor
0.6
Publication Type
Both (Printed and Online)
Volume
11
Year
2023
Pages
11