Synthesis, Identification, Thermal Analysis, Computational, And Antibacterial Studies of Z-N'-(5-Bromothiophen-2-yl)Methylene)Nicotinohydrazid
- Publication Type
- Original research
- Authors
- Hussam Yahya
- Ahmad Abu-Obaid
- Ashraf Sawafta
- Dyala Abu-Aladel
- Ahmad I. Asadi
- Rami Shariah
- Tasneem Alayed
- Ismail Warad
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N'-((5-bromothiophen-2-yl)methylene)nicotinohydrazide Schiff base was isolated and characterized as Zisomer. Ethanoic reflux condensation of equivalent amount of nicotinohydrazideand with 5bromothiophene-2-carbaldehyde produced the desired compound in good yield. The condensation reaction was monitored by FT-IR and UV-visible as well as DFT calculation. The structure of desired compound wasexperimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR spectral, TG/DTG and 1H-NMR.DFT-computational calculation supportedZ- isomer as favorited product over E one, good accordance between experimental and theoretical calculated were recorded. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.
Journal
- Title
- Moroccan Journal of Chemistry 4(1),259-269
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 2016
- Pages
- --