This study sought to know the effectiveness of using three interactive computer programs (GeoGebra, Graphmatica and Function Grapher) in the motivation of the students of the tenth grade towards learning mathematics in the Palestine. The two researchers used the experimental approach with semi-experimental design, by applying the study to a sample of (110) of the students of the tenth grade in the Directorate of Qabatiya (Palestine) for the academic year of 2015-2016. The sample of the study was divided into four groups in a random manner. In this study, the measure of motivation towards learning mathematics was used to include (20) paragraphs. The results of the study showed that there were statistically significant differences between the four groups and in favor of the three programs. The study concluded to a number of recommendations including: the necessity of applying the teaching method using the interactive computer programs especially (GeoGebra, Graphmatica and Function Grapher) due to their effect of favorability and clear efficacy in developing motivation toward learning mathematics.