Background: Discovering and screening for potential anti-obesity, anti-diabetic, anticancer, and antioxidant treatments
from natural products still in recent times the main goal for many pharmaceutical scientists. The present
investigation aimed to evaluate the chemical constituents of Ephedra alata fruits various extracts and to assess their
antioxidant, antiobesity, antidiabetic, and cytotoxic effects.
Result: In this work, high content of flavonoids and phenols were observed in the methanol fraction of E. alata fruits,
which reached 98.95 mg of RUE/g and 33.22 mg of GAE/g, respectively. The methanol fraction has significant inhibitory
activity against DPPH, α-amylase, α-glucosidase, and lipase with an IC50
value of 1.07, 9.43, 46.16, and 66.48 μg/
mL. respectively. Also has anticancer activity against HeLa cancer cell line. While the acetone fraction has potent
antioxidant activity with IC50
5 μg/mL.
Conclusion: The DPPH and digestive enzymes assays results showed that the methanolic fraction of E. alata fruits
has potent antioxidant, anti-diabetic, and anti-obesity activities, which can be an excellent candidate for biological
and chemical analysis

Title

BMC Chemistry

Publisher

Biomed Central

Publisher Country

United Kingdom

Indexing

Thomson Reuters

Impact Factor

2.6

Publication Type

Online only

Volume

15

Year

2021

Pages

41-51