One-Pot Combination of the Wittig Olefination with Bromination and Oxidation Reactions
- Publication Type
- Original research
- Authors
- Usama Karama
- Refat Mahfouz
- Zeid Al-Othman
- Ismail Warad
- Abdulrahman Almansour
A simple one-pot process for in situ bromination of (ethoxycarbonylmethylene)-triphenylphosphorane 1 was carried out. This was followed by oxidation of alcohol using SO3. Pyridine complex as a mild oxidant and in situ trapping of the aldehyde. This process constitutes a stereoselective one-pot procedure for the preparation of Z-configured α-bromo-α, β-unsaturated esters in good yield.
Journal
- Title
- Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry Volume 43, Issue 6, pages 893-898, 2013
- Publisher
- --
- Publisher Country
- Palestine
- Publication Type
- Both (Printed and Online)
- Volume
- --
- Year
- 2013
- Pages
- --