The rapid development in technology and the rapid increase in knowledge that has changed the context of what and how it is learnt has placed greater demands on education systems. Recently a new approach; e-learning has appeared in education system; learning –teaching process. E-learning, refers to use of computers and communication technologies in the teaching learning process, with the intention to enhance its effectiveness. Specifically blended learning, is one of the –learning forms that was used at An-Najah national university; it is to blend traditional classroom-learning style with web based style components. Aim of study: The study aimed to explore students' attitudes toward the experience of e-learning and identify the main challenges and problems facing them. Identification and exploration of e-learning challenges and problems that encounter students will help the university to identify e-learning strategies to meet learners’ and teachers' needs and how teachers and learners come to accept and use an e-learning style as well. Study design: Cross-sectional descriptive method was used to collect data using a self-administrative questionnaire. Sampling method and sample size: simple random method was used to select 8 from 48 courses and a convenient sampling method was used to select 302 undergraduate students who completed Blended Approach in e-Learning during the first semester of 2012 at An-Njah National University. The self-administrative questionnaire was used to collect data composed of three domains containing 32 statements of 5 choices of leckert scale Results: Students’ attitudes toward learning as high as (70.13) of students who completed the e-learning courses got a high score with a mean (3.5066). There were no significant differences between attitudes of students who completed the blended e-learning courses and their gender at the level of α= 0.05. There were no significant differences between attitudes of students who completed the blended e-learning courses and their academic year at the level of α= 0.05, while the significant differences were between the technical part and their academic year for the fourth year. There were significant differences between attitudes of students who completed the blended e-learning courses and their specialization at the level of α= 0.05. Recommendation: more training in the related technical domain of e-learning for newly enrolled students, more studies are needed to explore the differences among students in relation to specialization.