ABSTRACT:

Background: Man  used  various  natural  materials as  a  remedy  for  the treatment of various  diseases   and   recently  witnessed  a vastly  growing  and   renewed  interest  in herbal  medicine globally. In Palestinian folk medicine, Crataegus aronia is used as diuretics and for   the treatment of   hypertension.

Objectives: This study aimed to evaluate the diuretic effect of the aqueous extracts of this plant in mice after intraperitonial administration.

Methods: It is an  experimental trial applied to mice (n=12 male, CD-1, weight range:[ 25-30]g),  which  are divided  into three groups (4 in each) : first  group  administered  with  the  plant  extract (500 mg/kg), the second with  normal saline  as negative control group  and  the  third  with  furosemide  (10 mg/kg) as  positive control.  Then,  urine  output  and  electrolyte contents  were  quantified up to 6 hours  for the  three groups  and  then compared. Results were analyzed using SPSS program.

Results: The aqueous extract of C. aronia produced significant diuresis (p < 0.05). Moreover, aqueous extracts had an acidic PH (6.5125). The aqueous extracts of C. aronia  tended  an   increase  in  sodium  loss  compared  to   the negative  control  group, but  the  results  were   not  significant  statistically  for  sodium (P-value 0.068).

Conclusion: Our  investigations  significantly  revealed  that  C. aronia  aqueous extract  had  a potential  diuretic effect  which  can  be utilized for the treatment of hypertension and other  diseases  related   to  diuresis  and also  for  manufacturing  natural  and  safe  diuretic  drugs.

Title

Palestinian Medical and Pharmaceutical Journal

Publisher

An-Najah National University

Publisher Country

Palestine

Publication Type

Both (Printed and Online)

Volume

6

Year

2021

Pages

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