The Corona pandemic created the largest interruption of the education system in history. All countries of the world were affected by this, and the damage reached all educational institutions for all ages. Distance learning was one of the solutions that universities created to complete their educational path. Based on that, this study aimed to explore the challenges that students face during distance learning in light of the Corona pandemic. The study followed the descriptive analytical approach. A questionnaire was prepared that included (44) items distributed over its three fields: Academic Challenges, Psychological Challenges and Technical Challenges, applied to a random sample of (339) undergraduate and postgraduate students from An-Najah National University in the first semester of 2020/2021. Data were analyzed using Descriptive Statistics, Independent Samples t-test. The results of the study showed that the field of Psychological Challenges ranked first, followed by Academic Challenges, and then Technical Challenges came in the last. There were also statistically significant differences attributed to the study program variable in terms of the challenges facing students in distance learning in light of the Corona pandemic for the benefit of undergraduate students. the results showed that there is statistically significant differences attributed to the faculty variable in the two fields, academic and psychological challenges in favor of scientific colleges. There are also statistically significant differences attributed to the GPA variable in the two fields, academic and psychological challenges, in favor of students whose rates are acceptable.