Abstract. Breast cancer (BC) is the most frequent type of malignancy affecting females worldwide. Molecular–based studies
resulted in an identification of at least four subtypes of breast carcinoma, including luminal A and luminal B, Human growth
factor receptor (HER-2)-enriched and triple-negative tumors (basal-like and normal breast-like). A proportion of BC cases are of
the triple-negative breast cancer (TNBC) type. TNBC lacks the expression of estrogen receptor (ER), progesterone receptor (PR),
and HER-2, and is known to express androgen receptor (AR) at considerable levels. AR has been shown to promote the progression
of TNBC. However, the exact mechanisms have yet to be unraveled. One of these mechanisms could be through regulating the
expression of microRNA (miRNA) molecules, which play an important regulatory role in BC through post-transcriptional gene
silencing. Activation of AR controls the expression of miRNA molecules, which target selective mRNAs, consequently, affecting
protein expression. In this review we attempt to elucidate the relations between AR and miRNA in TNBC.

Title

Breast Disease

Publisher

An-Najah National University

Publisher Country

Palestine

Indexing

Scopus

Impact Factor

1.6

Publication Type

Online only

Volume

39

Year

2020

Pages

13