Introduction

Herbal medicine has been useful in the treatment of various diseases and has played a critical role in the discovery of new drugs. This study aimed to investigate the phytoconstituents, antioxidant, antidiabetic, and antiobesity activities of the traditional medicinal plant, Echium angustifolium Mill.

Methods

The constituents of E.angustifolium four solvents fractions were established utilizing conventional analytical methods. Antioxidant, antilipase, anti-glucosidase, and anti-α-amylase activities of E. angustifolium were conducted using DPPH (1,1-diphenyl-2-picrylhydrazyl α), p-nitrophenyl butyrate, P-NPG (4-nitrophenyl β-d-glucopyranoside), and dinitrosalicylic acid procedures, respectively.

Results

The methanolic fraction of E. angustifolium displayed inherent antioxidant properties with an IC₅₀ value of 1.95 μg/mL. Moreover, the hexane fraction presented potential α-amylase inhibitory activity with an IC₅₀ value of 92.89 μg/mL. Additionally, the aqueous fraction had the highest antilipase activity with an IC₅₀ value of 24.54 μg/mL.

Conclusion

It can be concluded that E. angustifolium has a high potential for development as an alternative approach for oxidative stress, diabetes, and obesity.

 

Title

European Journal of Integrative Medicine

Publisher

Elsevier

Publisher Country

Germany

Indexing

Scopus

Impact Factor

0.974

Publication Type

Online only

Volume

--

Year

2020

Pages

101196