Sudden Infant Death Syndrome (SIDS) represents a major leading cause of death among all racial and ethnic groups of infants between one month and one year of age. The exact cause of sudden unexpected death is still unclear, but there are multiple possibilities which presumed to explain it, such as: cardiovascular abnormalities, suffocation and infectious diseases. The occurrence of such death is extremely rare particularly in twins. For the first time in Palestine, we report a case of eightweek-old female twin who were found dead while sleeping on their right side. Their death occurred within 24 hours from each other. Extensive investigations were performed; no identifiable cause of death was discovered. This report demonstrates that low socioeconomic status of the family and unhealthy sleeping environment strongly influenced the sudden death of those monozygotic twin.