Purpose: Fusidic acid (FA) and sodium fusidate (SF) have problems in their skin penetration
and stability resulting in a reduction in their potency; therefore, the objective of this study was to
develop FA and SF nanoemulgels to improve the antibacterial activity of the drugs.
Methods: FA and SF nanoemulgel formulations were prepared by the incorporation of FA and
SF nanoemulsions with Carbopol hydrogel. First, the drugs were screened for their solubility in
different oils and surfactants to choose the suitable oil and surfactants for the drugs, and then the
drug nanoemulsion formulations were prepared by a self-nanoemulsifying technique using
Tween 80, Span 20 and pine oil. The drug nanoemulgels were evaluated for their particle size,
polydispersity index (PDI), rheological behaviour, drug release and anti-microbial activity.
Results: Based on the solubility test, pine oil was the best solubilising oil for both drugs,
Tween 80 and Span 20 showed the highest solubilising ability for both the drugs among the
surfactants; therefore, they were chosen as surfactant and co-surfactant, respectively. The
optimum self-nanoemulsifying formulations showed a particle size for fusidic acid and
Sodium fusidate of 140.58 nm and 151.86 nm respectively, and both showed a low PDI
below 0.3. After incorporating both drug SNEDDS formulations with Carbopol at different
concentrations, the results of the drugs particle size and PDI showed no significant difference.
The zeta potential results for both drugs nanoemulgels showed a negative potential
with more than 30 mV. All nanoemulgel formulations showed pseudo-plastic behaviour with
the highest release pattern at 0.4% Carbopol. The antibacterial activity of both drug nanoemulgel
formulations showed superiority over the market product.
Conclusion: Nanoemulgel is a promising delivery system for FA and SF that helps in
improving the stability and antibacterial activities of the drugs.

Title

International Journal of Nanomedicine

Publisher

Dove Press Ltd

Publisher Country

Canada

Indexing

Thomson Reuters

Impact Factor

4.471

Publication Type

Prtinted only

Volume

14

Year

2019

Pages

9411–9421