Background: The clinical implications of food-drug interactions may have to be taken seriously into accountwith
oral drugs administration in order to minimize variations in drug bioavailability. Food intakemay alter physiological
changes in the pH and viscosity of the gastrointestinal lumen, which could affect the oral absorption of drugs.
Purpose: The aim of the present study was to have an insight on the effect of media parameters: viscosity and
pHon the oral absorption of ciprofloxacin HCl from solid formulations using a model food: Corchorus olitorius
(Jute) Soup.
Methods: In vitro disintegration and dissolution rates of ciprofloxacin tablet were evaluated using compendia
buffer media in the presence/absence of C. olitorius leaves. These in vitro data were then input to GastroPlus™
to predict ciprofloxacin absorption profiles under fasted and fed states.
Results: The present study demonstrated the significance of luminal pH and viscosity on the dissolution and disintegration
of solid formulations following postprandial ingestion of the viscous soup. The tablets showed
prolonged disintegration times and reduced dissolution rates in this soup, which could be attributed to the postprandial
elevation inmedia viscosity and reduced solubility at elevated gastricpH. The predictedmodel under fed
state showed no impact on AUC but prolonged Tmax and a decrease in Cmax.
Conclusion: Concomitant intake of C. olitorius soup with ciprofloxacin might have negative effect on the rate of
drug release from conventional immediate release tablets.

العنوان

European Journal of Pharmaceutical Sciences

الناشر

Elsevier

بلد الناشر

هولندا

Indexing

Thomson Reuters

معامل التأثير

3,773

نوع المنشور

مطبوع فقط

المجلد

101

السنة

2017

الصفحات

100-106