Recently, essential oils (EOs) have garnered attention for their biological properties
as a source of natural compounds with anticancer, antibacterial, and antioxidant
effects. Chiliadenus iphionoides (Boiss.& Blanche) Brullo is a fragrant aromatic
species indigenous to Palestine and the neighboring countries. It is utilized by the
Bedouins for the treatment of many ailments. This study aimed to analyze the chemical composition of essential oil extracted from the desiccated leaves of Chiliadenus
iphionoides (Boiss.& Blanche) Brullo and to assess its in vitro antioxidant, anticancer,
and α-amylase and lipase inhibitory activities. The EO obtained during hydrodistillation was analyzed using gas chromatography-mass spectrometry to ascertain their
chemical composition. GC-MS analysis of the EO from dried Chiliadenus iphionoides
(Boiss.& Blanche) Brullo leaves identified 47 compounds, comprising 98.81% of the
total oil. The predominant constituents included cresol methyl ether (52.93%), ethyl
2-octynoate (14.36%), epi-α-cadinol (6.56%), 1,8-cineole (4.25%), and 7-epi-
α-eudesmol (3.66%). The EO exhibited significant antioxidant activity against
1,1-diphenyl-2-picrylhydrazyl (DPPH) with an IC50 value of 19.83±0.99 μg/mL. Nevertheless, it exhibited limited lipase activity and subpar α-amylase activity. Chiliadenus
iphionoides (Boiss.& Blanche) Brullo EO exhibited significant cytotoxicity against
B16F10 and MCF-7 cancer cell lines, with IC50 values of 8.74±0.11 and 13.68±0.17
μg/mL, respectively. The combination of the anticancer medication Taxol (10ng) with
Chiliadenus iphionoides (Boiss.& Blanche) Brullo EO at concentrations of 25 μg/mL
and 50 μg/mL significantly enhanced the inhibitory efficacy of Taxol against MCF-7
and B16F10 cells
 

العنوان

PLoS One

الناشر

Public Library of Science (PLOS)

بلد الناشر

الولايات المتحدة الأمريكية

Indexing

Scopus

معامل التأثير

2,9

نوع المنشور

مطبوع فقط

المجلد

20

السنة

2025

الصفحات

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