Isotope labeling of α-amino acids is a crucial tool for drug discovery and understanding biochemical processes. The goal
for this work was to develop a fast exchange condition to prepare D-[13C]phenylalanine in a short time with high incorporation of 13C isotope, which could be translated to 11C-α-amino acid. In this work the exchange reactions on preformed imine
carboxylate by using [13C]CO2 gave some evidence that the fast exchange to enable direct radiolabeling of α-amino acids,
using [11C]CO2, could be possible.
 

العنوان

Journal of Radioanalytical and Nuclear Chemistry

الناشر

Springer (Springer Nature)

بلد الناشر

ألمانيا

Indexing

Scopus

معامل التأثير

1,6

نوع المنشور

مطبوع فقط

المجلد

334

السنة

2025

الصفحات

3669–3682