N-Acetylcysteine-Induced Headache In Hospitalized Patients With Acute Acetaminophen Overdose
نوع المنشور
بحث أصيل
المؤلفون
النص الكامل
تحميل

Intravenous N-acetylcysteine (IV-NAC) is usually regarded as a safe antidote to acetaminophen overdose. However, during infusion of the loading dose, adverse drug reactions such as a headache may occur. The objectives of this study were to investigate the prevalence of headache in patients presenting to hospital after acetaminophen overdose and to determine which clinical findings are most predictive of headache among these patients. This is a retrospective cohort study of hospital admissions for acute acetaminophen overdose that was conducted over a period of 4 years from January 1, 2005 to December 31, 2008. Demographic data, clinical characteristics, and predictors of headache were analyzed. spss 15 was used for data analysis. Two-hundred and fifty-five patients were studied; their mean age was 23.1 ± 1.6; 83.9% of them were women and 14.9% had a headache during hospitalization. Headache among patients was significantly associated with IV-NAC administration (P = 0.001), intentional ingestion of drug (P = 0.04), acetaminophen concentration above ‘possible toxicity’ treatment line (P = 0.04), a high acetaminophen concentration (P = 0.04), and a long hospital stay (P = 0.03). Multiple logistic regression showed a significant risk factor for headache in patients administered IV-NAC (P = 0.04). We recorded a high frequency of headache in patients with acute acetaminophen overdose in our geographical area. This study suggests that among those patients, the use of IV-NAC is associated with an increased risk of headache.

المجلة
العنوان
Fundamental & Clinical Pharmacology; Volume 25, Issue 3, June 2011, Pages: 405–410
الناشر
Wiley
بلد الناشر
الولايات المتحدة الأمريكية
Indexing
Thomson Reuters
معامل التأثير
2,319
نوع المنشور
Both (Printed and Online)
المجلد
25
السنة
2011
الصفحات
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