Abstract: Lavandula dentata L. and Origanum syriacum L. essential oils have various reputed biological and physiological properties in humans, indicating common components that have a variant degree of depressive actions in the central nervous system. AMPAR is responsible for most of the fast-excitatory neurotransmission in the central nervous system, and they critically contribute to the synaptic plasticity and several pathologies such as Alzheimer’s disease, Epilepsy, Amyotrophic Lateral Sclerosis, and Stroke in the brain. The chemical compositions of L. dentata flowers and O. syriacum leaves essential oils were characterized utilizing Gas chromatography mass spectrometry (GC/MS). The results showed that the major compositions of L. dentata essential oil were linalyl acetate and linalool while the major ingredients of O. syriacum were p-thymol and carvacrol. To study their effects on AMPA receptors, Human Embryonic Kidney Cells 293 (HEK293 cells) were transfected with plasmids to express different types of Glutamate AMPA receptors, then whole cell currents were measured with and without the administration of the oils to study the biophysical properties of the receptors. Data acquisition and analysis of the biophysical properties of AMPA receptor subunits with and without the L. dentata and O. syriacum essential oils showed that O. syriacum oil reduces desensitization of GluA1, GluA2 homomers, and GluA1/2 heteromers, albeit less than L. dentata oil and L. dentata slows deactivation kinetics of GluA1, GluA2 homomers, and GluA1/2 heteromers, but slightly higher than O. syriacum. In addition, recording in a discrete number of AMPA receptor homomeric and heteromeric subunits expressed in Human Embryonic Kidney Cells 293 (HEK293) in the absence and presence of extracted L. dentata and O. syriacum essential oils did not show any statistically significant changes. These data suggest that the two oils contain components that are worthy of focus to identify as those active components underly the oils’ neuronal inhibitory properties reported and to extract them to potentially synthesize a neuroprotective drug effective to treat neurodegenerative diseases and epilepsy.

عنوان المؤتمر

7th international Drug Chemistry Conference

دولة المؤتمر

تركيا

تاريخ المؤتمر

14 مارس، 2019 - 17 مارس، 2019

راعي المؤتمر

Many pharmaceutical companies, universities and publishers

معلومات إضافية

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